CM – Hybrid human-animal research raises hopes and concerns

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Scientists have successfully grown embryos that contain a combination of human and monkey cells. This is a major breakthrough in a rapidly advancing field of genetics that researchers say could one day revolutionize our understanding of human development.

An international team of scientists led by Juan Carlos Izpisua Belmonte from the Salk Institute in La Jolla, California, injected human stem cells into monkey embryos and watched the two different groups of cells develop together. None of the embryos survived longer than 19 days, but experts say the experiment still marks a significant advance in the science of inter-species hybrids – known as chimeras.

The same scientists had successfully created pig and sheep embryos using human cells, however, experimented with primates after only a tiny percentage of cells survived in these tests. Researchers hope that one day in the near future, fully-fledged human-animal chimeras may provide insight into the earliest stages of human development, improve understanding of how certain diseases can be treated, and even provide organs for human transplants The science of combining genes from two animals dates back to the 1970s. However, new technologies have resulted in a number of breakthroughs in recent years. Despite all the potential promises, chimera research is also controversial. Many countries, including the United States, have at times restricted experiments with non-human embryos containing human cells. The National Institutes of Health, a government agency that is the largest source of biomedical research funding in the United States, has banned the use of federal dollars in studies of human-animal chimeras.

Despite all promises, hybrid embryos raise ethical questions that have led many experts in the field to argue against further research. A noted bioethicist said that even in their early stages, these experiments « open Pandora’s box » to a future in which living hybrid human-non-human animals can be reared to full maturity. This situation, they argue, raises questions about how much human material a monkey can have before it is actually human itself.

There are also concerns about how much control can be exercised over what parts of the body contain human cells. For example, a chimera with human genetic material in the liver is much less of a concern than a chimera with human DNA in the brain or in reproductive cells. Of course, there are also animal rights activists who oppose all scientific animal testing.

The scientists who created the monkey-human embryos acknowledge these dilemmas and consulted several bioethicists while developing their research. In their view, the potential benefits chimeras could offer make further study worthwhile. They say hybrid embryos can be used in experiments that can be done on humans for legal and moral reasons. That freedom could provide insights that transform understanding of the earliest stages of human development and reveal new therapies for chronic diseases, Belmonte said. He added that organ donation from chimeras could prevent thousands of people from dying on transplant waiting lists each year in the U.S. alone.

Hybrid embryo research has a long way to go before any of the more difficult ethical issues being tested in the real world. In the next month, the International Society for Stem Cell Research is expected to publish updated guidelines that could set new standards for the acceptance of human-animal hybrid research. The NIH says it will wait for these new rules before deciding whether to lift its funding ban on chimera research in the US.

« Such research should always be conducted with caution and properly monitored. But it should also be encouraged as the rewards associated with it could turn out to be significant. Chimeric embryos may provide a way to circumvent ethical issues that make experimentation with human embryos difficult. This could lead to new treatments for congenital diseases. … Eliminating the longstanding global shortage of transplantable organs could save many lives. « – Economist

 » This work crosses crucial moral boundaries. These human monkey cells would not only have been bone or kidney tissue, but also brain neurons. Furthermore, we are not talking about mice or rats, but rather monkeys, who have a much closer genetic affinity with humans. What could result from such a combination? I don’t think we should find out. « – Wesley J. Smith, National Review

 » Extending the concept to our own species calls into question the idea of ​​the human state of emergency. What moral status could such a creature have? Would its human cells have an impact on brain development and have animal consciousness? How do we know? « – Oliver Duff, iNews

 » At the time of the first airplane, all potential applications existed only in the minds of a few people. If society decided that it was a terrible idea for humans to fly, we would be missing many things that turn out to be wonderful for everyone. A society that sees the world for what it is, not what it should be, is an effective society that can evolve. « – Human-animal embryo researcher Jian Feng at CNN

 » A liver is a type of liver, it doesn’t seem to have too many special properties, but the sperm and egg and brain are part of a person. It So it feels a lot more ethical to breed a person in a pig than to breed just part of a person. Someone has a heart transplant or a liver transplant, and that somehow seems to make more sense. ”- Neuroscientist Francis Shen to the scientist / p> « I don’t think it’s particularly worrying about ethics because you’re not getting them far enough to have a nervous system or develop in any way – it’s really just a ball of cells. … [But] if you allow these animals to go all the way and be born, if you make a great contribution to the human nervous system from the human cells, then obviously this becomes a problem. « – Developmental Biologist Robin Lovell Badge to the Guardian

 » These concerns about chimeric research add to the already grave ethical problems associated with general invasive animal research. Every year tens of millions of animals are sick, injured, genetically manipulated and killed in biomedical laboratories. … Chimera research will only exacerbate animal suffering and bring it into areas of unforeseen consequences for which we are completely unprepared. « – Lori Marino, Stat

 » I don’t think we’re on the edge of the ‘planet of the apes’. I think there are few rogue scientists out there. But they’re not zero. So I think it’s one appropriate time for us to ponder, “Should we ever let this go beyond a petri dish?” – Bioethicist Hank Greely to NPR

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Social media makeup consultant and entrepreneur Jeffree Star is in « excruciating pain » but survived a car accident in Wyoming this morning that left him hospitalized. Star and Daniel Lucas were driving in Wyoming when they encountered a piece of black ice. According to Star’s social media accounts, their car turned three times. Stern is now […]

A teenager who was killed in a shootout in a shopping mall in Nebraska that killed a man and a woman was injured, was arrested on Sunday on a murder warrant, police said. Omaha police said 16-year-old Makhi Woolridge-Jones would be charged with first degree murder on Saturday at the Westroads Mall in Omaha. 18-year-old Brandon Woolridge-Jones was previously arrested on charges of being involved in the shooting.

A giant Stone Age house was reconstructed using only the prehistoric tools and techniques our ancestors would have recognized 5,000 years ago . Makeshift bone chisels and stone axes have created an entire thatched wooden building at Butser Ancient Farm in the Hampshire South Downs. In a groundbreaking project, archaeologists traced evidence from the remains of an actual house found in Berkshire in 2012 – the home of early farmers around 3,800 BC. The building is covered with a shaggy thatched roof that extends from the roof to the floor. Claire Walton, an archaeologist at Butser, told The Telegraph that it looks exactly like Doogle, the long-haired dog from The Magic Roundabout, the children’s television classic. « Somebody pointed it out and I can’t get it out of my head right now, but it’s a good analogy, » she said. She spoke of her amazement at how efficient the most basic ancient tools were. « People keep calling It’s the Stone Age, which is such a misnomer because we discovered that bone was such a useful tool, » added Ms. Walton. « What is usually discovered are the stone tools and hand axes, and not things like bone chisels. We actually used bone chisels, for example, to drill holes that we drove herrings into. Bone chisels proved remarkably effective, with almost no preparation to work on [that ]… That was pretty enlightening. ”Drawing on the skills of early Neolithic man, the archaeologists used stone hand axes to shape the timbers and split hazelnuts for more detailed elements – such as a decorative hazelnut feature above the door (pictured below) with a piece of flint.

Months after President Joe Biden’s inauguration, One America News Network, a right-wing cable news broadcaster that is available in approximately 35 million households, continued to broadcast segments questioning the validity of the 2020 presidential election. « There are still serious doubts about who actually P President, « OAN correspondent Pearson Sharp said in a March 28 report. This segment was one of a series of similar reports from a broadcaster that has become sort of Trump TV for the post-Trump era, a point of sale whose coverage coincides with the former president’s complaints at a time when he was relieved by the most important social media is excluded from platforms. Sign up for The Morning Newsletter from the New York Times. Some of OAN’s reporting was not fully supported by staff. In interviews with 18 current and former OAN newsroom staff, 16 said the broadcaster had broadcast reports they believed to be misleading, inaccurate or untrue. After much of OAN’s coverage, it is almost as if there never was a transfer of power. The broadcaster did not broadcast any live coverage of Biden’s swearing-in ceremony and inaugural speech. Through April, Donald Trump was consistently referred to as « President Trump » and Biden only as « Joe Biden » or « Biden » in news articles on the OAN website. This practice is not followed by other news organizations including OAN competitor Newsmax, a conservative cable channel and news site. OAN has also advocated the debunked theory that the rioters who stormed the Capitol on January 6 were leftist agitators. Towards the end of a March 4 news segment describing the attack as the work of “anti-fascists” and “anti-Trump extremists” and describing the president as “Beijing Biden,” Sharp said, “History will show that it was the Democrats, not the Republicans, who called for this violence. “Research has found no evidence that people who identify with Antifa, a loose collective of anti-fascist activists, were implicated in the Capitol uprising. Charles Herring, president of Herring Networks, the company that owns OAN, defended the reports that cast doubt on the election. « Based on our research, the November 2020 elections clearly revealed irregularities among voters, » he said. « The real question is to what extent. » Herring Networks was founded by Hering’s father, technology entrepreneur Robert Herring, who ran the OAN at the age of 79 with Charles and one other son, Robert Jr. Around 150 employees work for the station at its headquarters in San Diego. Nielsen does not report audience stats for OAN that is not a Nielsen client. (Charles Herring cited Nielsen’s « high fees ».) In a poll last month, Pew Research reported that 7% of Americans, including 14% of Republicans, had received political news from the OAN. In contrast, 43% of Americans and 62% of Republicans had received political news from Fox News, according to the poll. While OAN appeals to a relatively small audience, its coverage reflects the views of Republicans. In a Reuters / Ipsos poll last month, around half of Republicans said the January 6 attack, which killed five people, was largely a nonviolent protest or the work of leftist activists. Six in ten Republicans polled said they believed Trump’s claim that the election was « stolen ». OAN, which began in 2013, gained attention when it fully aired Trump’s campaign speeches ahead of the 2016 election. In recent months, it has been wooing viewers who may have felt abandoned by Fox News, which on election night was the first news agency to project Biden as the winner from Arizona, a major swing state. In an advertisement in mid-November, OAN accused Fox News of « joining the mainstream media in censoring factual reports. » OAN’s stories « speak to people who want to believe the choice was illegitimate, » said Stephanie Edgerly, associate professor at Northwestern University’s Medill School of Journalism. « These are two mutually reinforcing narratives from people who believe it and want to keep fueling the fire of OAN. » Marty Golingan, the station’s producer since 2016, said OAN has changed in recent years. When he first started, the company focused more on neutral reporting based on reports from The Associated Press or Reuters. He saw it as a scratchy upstart to produce naughty feature films, he said. It moved to the right during the Trump presidency, Golingan said. And as he watched the coverage of the pro-Trump crowd breaking into the Capitol, he feared that his work might inspire the attack. He added that he and others at OAN disagreed with much of the broadcaster’s coverage. « The majority of people did not believe that the allegations of electoral fraud are in the air, » Golingan said in an interview, referring to his colleagues. He remembered seeing a photo of someone in the Capitol holding a flag with the OAN logo on it. « I thought, OK, this is not good, » said Golingan. « That happens when people listen to us. » Charles Herring defended OAN’s coverage. « A review process with multiple reviews is in place to ensure reporting is up to the company’s journalistic standards, » he said. « And yes, we’ve had a lot of mistakes, but we’re doing our best to keep them to a minimum and learn from our missteps. » Golingan added that Lindsay Oakley, the OAN’s news director, had reprimanded him since inauguration day for referring to Biden as « President Biden » in a message. Oakley did not respond to requests for comment. « OAN White House staff use the term President Biden and then possibly Mr. Biden, » said Charles Herring. « The term biden or biden administration can also be used. » He declined to respond to a question about the broadcaster’s use of « President Trump » for Trump. Allysia Britton, a news producer, said she was one of more than a dozen employees who left OAN after the Capitol uprising. She criticized some of the station’s reports, saying it did not meet journalistic standards. « Lots of people have raised concerns, » Britton said in an interview. « And the thing is, if people talk about anything, you’re going to get in trouble. » Charles Herring confirmed that about a dozen OAN employees had left in the past few months, saying many of them were not high-level employees. Jobs that the older Herring has a particular interest in are referred to as « H-stories » by OAN employees, said several current and former employees. The day after Trump supporters stormed the Capitol, Herring instructed OAN staff to « report all things Antifa did yesterday » in an email audited by the New York Times. Some « H-Stories » are reported by Kristian Rouz, an OAN correspondent who wrote for Sputnik, a website supported by the Russian government. In a report on the pandemic in May, Rouz said COVID-19 may have started as a « globalist conspiracy to establish comprehensive population control » that had ties to Bill and Hillary Clinton, billionaires George Soros and Bill Gates, and « the deep » state Britton, the former OAN producer, recalled checking out a website that Rouz had quoted in support of some of his reports. « It literally took me to this chat room where only conservatives comment on each other » « She said. In an email to staff last month, Oakley, the news director, warned producers not to ignore or downplay Rouz’s work. » His stories should be viewed and treated as « H-stories »  » , she wrote in the email the Times checked, « These stories are often edited and copied by ME according to Mr. H’s instructions. » The online Pooh OAN’s blikum is significant with nearly 1.5 million subscribers to the YouTube channel. One of the most popular videos, with around 1.5 million views since it launched on Nov. 24, criticized Dominion Voting Systems, the voting technology company whose equipment has been used in more than two dozen states over the past year, including several that Trump won Has. The video, hosted by OAN White House correspondent Chanel Rion, shows a man saying he infiltrated Dominion and overheard company executives say they would « make sure » Trump is lost. Dominion has sued Fox News and two of Trump’s attorneys, Rudy Giuliani and Sidney Powell, on charges of making or promoting defamatory claims. A Dominion attorney who failed to respond to requests for comment said the company was considering further legal action. Golingan, the producer, said some OAN employees were hoping Dominion would sue the broadcaster. “A lot of people said, ‘This is crazy, and if they sue us, we might stop posting such stories,” he said. Weeks after Dominion filed its first libel suits, OAN broadcast a two-hour video of the executive director of MyPillow, Mike Lindell, set out his case that there was widespread electoral fraud. YouTube removed the video on the day it was posted and said it violated the platform’s election integrity policy last month An OAN report called Dominion’s “voting machines” “notorious.” Two of the current and former employees interviewed for this article – Dan Ball, a talk show host, and Neil McCabe, a former reporter – described the coverage by OAN as impartial. McCabe, who now writes for The Tennessee Star, said the network « gave people a voice who. » just aren’t covered « . This article originally appeared in the New York Times. © 2021 The New York Times Company

President Joe Biden made his first shot in a President pastime: golf. Once an avid golfer, Biden played Saturday at Wilmington Country Club, not far from his Delaware home, where he spent the weekend. It was his first game of golf since taking office in January.

A visit to a frozen yogurt shop prompted the pop star to oppose « harmful news ».

NEW YORK – After Michelle Zauner for an hour Having talked about her mother, the afterlife, and the shamelessness sometimes required in the production of art, she set her video camera to show her apartment in Bushwick, Brooklyn. Her coffee table, which was suddenly in sight, was covered with Jolly Pong Cereal Snack, NongShim Shrimp Crackers, Lotte Malang cow’s milk drops and other Asian junk food. « We talked the whole time, » she said, « you were before those snacks. » These are her favorite strains from H Mart, the Korean-American supermarket chain that serves as both a muse and a refuge for her. Zauner, known for her Japanese Breakfast music project, wrote about the « beautiful, holy place » and the death of her mother Chongmi in an essay for The New Yorker « Crying in H Mart » from 2018, which led to a treatise with the same Name button released on Tuesday. Sign up for The Morning Newsletter from the New York Times. In the essay, which is the first chapter of her book, she recounted her grief, appetite, and fear that after losing Chongmi to cancer in 2014, I would “still be a Korean if no one could call and ask which ones Algae brand we bought earlier? “The rest of the memoir explores her identity as a biracial Asian American, the bonds food can make, and her efforts to understand and remember her mother. Zauner’s parents met in Seoul in the early 1980s when their father Joel moved there from the United States to sell cars to the US and Canadian military. Chongmi worked in the hotel where he was staying. They married after three months of dating and again toured Japan, Germany, and South Korea before ending up in Eugene, Oregon, where Michelle Zauner grew up. In early drafts of the book, she said during our interview, she tried to imagine what it was like for her mother to get married so quickly, to face a language barrier with her husband, and to keep uprooting herself. When she asked her father questions like « Do you remember how she felt? » He replied with geographic facts and figures. As with many immigration stories, the scarcity ran through much of what Zauner found while writing the book: In her family, her father was so focused on it that he couldn’t give her the emotional support she was looking for, while her mother was looking at identity crises as a waste of energy. “I have a feeling that parts of the book move her,” said Zauner, “but I think there are parts that she would think:“ I don’t know why you had to keep doing the whole book like this when you did you’re like an american kid. « Zauner, 32, writes about their volatile relationship, contrasting her mother’s reluctance to express herself, her sense of urgency that » no one can understand what I and I have been through, everyone needs to know. « After graduating from Bryn Mawr, she joined the Philadelphia rock band Little Big League in 2011 before setting up on her own as a Japanese Breakfast. Her first two solo albums, as well as her memoir, focused on grief: » Psychopomp « in 2016 and “Soft Sounds From Another Planet” in 2017. Her next album, “Jubilee”, is slated for release in June and is happier, influenced by Kate Bush, Bjork and Randy Newman. Between these projects she worked on video game soundtracks, made music videos and rushed into the literary world, reflecting her maximalist and, yes, shameless approach to creativity. « The thing about Michelle is, you just have to give her a little push in that direction – an affirmation – and suddenly she just flies, » said Daniel Torday, a novelist and director of the creative writing program at Bryn Mawr a mentor for Zauner. For her, the artistic process feels like whether in her he music or in her writing, often all consuming and fearful of something she deals with by working through it. « If I take the time to do something, » said Zauner, « I want to be afraid of it. » And there are terrifying parts she faces as she traces the last few months of her mother’s life. It’s not exactly cancer – in the book she describes the disease with polish by mashing Vicodin with a spoon for her mother and sprinkling its blue crumbs « like narcotic sprinkles » over balls of ice. It is that Chongmi was dying just when their relationship was at its best, « a kind of renaissance time where we could really enjoy each other’s company and get to know each other as adults, » Zauner said. In 2014 she moved home to take care of her. Chongmi died in October, two weeks after Michelle Zauner married Peter Bradley, a fellow musician. By Christmas he joined her and her father in Eugene, navigating the first difficult moment of their new life together – « like an adult baptism, » Bradley said. She and her father have not been in contact for more than a year, apart from one attempt at therapy via Zoom. After her mother’s death, « our grief could not come together in this way where we could experience it together, » said Zauner. « He started wearing that big ruby ​​in his ear and then got a big tattoo, lost 40 pounds, started dating this young woman and it felt like a second death. » In an essay for Harper’s Bazaar published this month, she wrote about the pain of the experience and then looked for a way to make peace with him and his new relationship that has now ended. Joel Zauner expressed his grief over their estrangement in a telephone interview. He avoided reading « Crying in H Mart » for months (Michelle Zauner sent him an advance copy), but when he did he cried through and was stung that it was not on the confirmations. The tattoo was done on the anniversary of Chongmi’s death, he said, and is called in Korean, including the Korean word for « treasure. » « I’m not the perfect guy, » he said. « But I definitely deserve more than I was given in both the article and the book. » Today, Zauner feels ready to shake this time of loss and just go on tour, and there are more she’d like to unpack to be Korean, possibly by living there for a year. « I think a lot of my sense of belonging is missing because I am not fluent in the language, » she said, determined to keep the thread that she has with the Korean side of her family. She was once absorbed in Emily Kim, known as Maangchi as « YouTube’s Korean Julia Child, » who found peace in the way she peeled Korean pears – « the Korean way, » Kim wrote in an email – and the knife to remove it, used the skin in a long strip, like Chongmi earlier. In 2019, the two starred in a vice video examining the effects of migration on the kitchen, and on Zauner’s 30th birthday, Kim made her dinner. « She’s a real Korean daughter, » said Kim. However, Zauner is concerned about her work in connection with the anti-Asian attacks over the past year. « Ich habe Angst, diese Tragödie zu nutzen, um für alles zu werben, was ich geschaffen habe », sagte sie am Tag nach den Schießereien in Atlanta in einer E-Mail. « Es ist ein wenig schwierig, meine Gefühle in so einer schweren Sache mit ein paar Worten zusammenzufassen. » Ihr Glaubenssystem ist nuancierter als zuvor. Sie ist Atheistin, « aber dann muss es für mich ein wenig Verschmieren der Kanten geben », sagte sie. « In gewisser Weise ist es mir unmöglich, nicht das Gefühl zu haben, dass meine Mutter nach mir Ausschau gehalten hat, weil die Dinge in meinem Leben zufällig und schicksalhaft passiert sind. » Vor fast einem Jahr, als sie mit dem Schreiben von „Crying in H Mart“ fertig war, veröffentlichte sie ein Foto von sich in ihrem Wohnzimmer mit geschlossenen Augen und einem friedlichen Lächeln, das den Entwurf des Buches in den Händen hielt, mit der Überschrift „Happy Mother’s Day , Mama. » Es gibt Fälle, in denen es wichtig ist, einen mehrdeutigen Raum für Dinge zu schaffen, obwohl dies gegen alles verstößt, was Sie glauben. « Wie wenn ich Blumen auf ihrem Grab liegen lasse, weiß ich technisch, was ich tue, ist, dass ich die Blumen für mich selbst lasse. Ich erstelle ein Ritual und gedenke ihr mit meiner Zeit, indem ich dies tue. Aber das reicht mir nicht, um mich in Ordnung zu fühlen “, sagte sie. « Ich muss irgendwie glauben, dass sie weiß, dass sie da sind. » Dieser Artikel erschien ursprünglich in der New York Times. © 2021 The New York Times Company

Terrence James, 49, aus Galveston, Texas, starb am 19. Februar 2021, nachdem er an COVID-19 erkrankt war. Er gehört zu den mehr als 565.000 Amerikanern, die seit dem ersten bekannten Todesfall in den USA Anfang 2020 der Krankheit erlegen sind.

His wife, Ebony James, told Yahoo News that her husband was a man of faith who fearlessly loved God and his family, and that he was also passionate about helping people.

“If someone told him about a problem or concern he had, he would always listen. He never missed an opportunity to say, « OK, let’s pray for this now, » said Ebony, adding that her husband « always went out of his way to let people know he cares. »

Niviane Petit Phelps, a Florida nurse, allegedly threatened the life of Vice President Kamala Harris in numerous videos sent to Phelps’ husband in prison.

China will expand digital yuan experiments to more cities, but there are no specific timetable for the official launch, Central Bank Vice Governor Li Bo said Sunday at an annual meeting of Chinese and overseas policy makers, executives and academics. China is at the forefront of the global race to adopt central bank digital currencies to modernize financial systems, ward off the threat of cryptocurrencies like Bitcoin, and accelerate domestic and international payments. According to Li, tests have shown that the digital yuan (e-CNY) issuing and distribution mechanism is compatible with the existing financial system, helping to minimize the impact on the banking sector.

The current rate is 21% after Trump cut it from 35% in 2017. Biden has proposed a rate of 28% to pay for his $ 2 trillion infrastructure plan.

Austin interim police chief Joseph Chacon says a 41-year-old man was killed in the fatal shooting of three people in Austin, Texas. Officials searching the area warn residents that the suspect may be held hostage. (April 18)

Hollywood legend Robert De Niro cannot refuse acting roles because he has to pay for the expensive tastes of his estranged wife, the actor’s lawyer has claimed. Caroline Krauss told a Manhattan court that he was facing financial problems over the pandemic, a massive tax burden, and claims from Grace Hightower, who filed for divorce in 2018 after 21 years of marriage. The court has been asked to clarify how much De Niro will pay Ms. Hightower, 66, until the terms of the marriage agreement the couple negotiated in 2004 come into effect. « Mr. De Niro is 77 years old and although he loves his craft, he shouldn’t be forced to work at this amazing pace because he has to, » Ms. Krauss told the court. “When does it stop? When does he get the opportunity not to take on every project and not work six days a week or twelve hours so that he can keep up with Ms. Hightower’s thirst for Stella McCartney? « 

A well-known conspiracy theorist from Norway who shared false information about the pandemic online has died of COVID-19, according to official reports.

She is said to be the Queen’s most popular daughter-in-law, and now she will become the monarch to the Countess of Wessex to fill the void the Duke and Duchess of Sussex have left in their royal duties, a 56-year-old Countess who was one of the most prominent members of the in the days following the Duke of Edinburgh’s death She made the first public comments on his death, repeatedly visiting Windsor Castle and providing a photo of the Queen and Duke at Balmoral that Her Majesty wanted to share with the world as a tribute to her late husband.

Four of the eight who died in a FedEx warehouse were members of the Sikh community.

Both are increasing their presence in the area, but only one has a real presence h strong West Coast vibe, while the other is fairly general.

Russell Montoya Jr. bought materials from a hardware store and made a makeshift grave under the stairs of his unfinished basement

Ref: https://news.yahoo.com

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