Petronas Yamaha rider Fabio Quartararo continues to lead the championship going into the sixth round of 2020, but his lead has been slashed to just three points after a difficult run of races since his two victories in the Jerez double header.
By contrast, KTM riders have been in the spotlight in the last three rounds, with Brad Binder and Miguel Oliveira taking a win each for the Austrian manufacturer.
Honda and Yamaha have underperformed in the opening part of the season, and both the Japanese marques would be looking for an improved showing in the first of the two races at Misano.
Finally, much would be expected from Ducati and its lead rider Andrea Dovizioso, who has closed the gap to Quartararo following his victory in the first Red Bull Ring race.
The San Marino GP will get underway at the Misano at 2pm local time (CEST) on Sunday. The race will be run over 28 laps and last approximately 45 minutes.
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No rain is expected at Misano on Sunday. According to the latest forecast, the minimum temperature will be 19C and the maximum temperature will be 27C.