World news – California – University of Alberta research team prepares to treat diabetes – once again

The team led by Dr.. . James Shapiro, has managed to treat diabetes in mice consistently and is now looking forward to moving to human trials.

Dr. James Shapiro, a liver transplant surgeon at the University of Alberta and director of liver transplantation programs at the Clinical Island and living donor with Alberta Health Services, checks the OrganOx Metra portable extracorporeal perfusion device – the first of its kind in North America – at University of Alberta Hospital on Wednesday, March 18, 2015. Photo by Claire Theobald / Edmonton Sun..

Nearly 20 years after a University of Alberta research group established a medical history by improving a treatment for diabetes, the same team is trying to do it again..

Dr.. James Shapiro and his research team at the university say they have been able to treat diabetes in mice, according to a CTV Alberta report.. The team is using a technology that involves developing stem cells into pancreatic cells that can produce insulin. They believe their research could translate into a functional human treatment for diabetes.

“We have worked with a company called ViaCyte in San Diego for nearly 19 years now, and this company has a cell derived from a human embryonic stem cell that makes human insulin in an orderly and perfect way,” Dr.. Shapiro said in the video search update. « We have been able to treat thousands of mice with these stem cells and treat mice with diabetes effectively over many years now..

In the late 1990s, Dr.. Shapiro and his team in Edmonton have improved the technique for transplanting insulin-producing islet cells from the donor’s pancreas into type 1 diabetes patients.. Their method, which relies on the use of a large number of islet cells of up to three different donors, was published in the New England Journal of Medicine in 2000 and became known as the « Edmonton Protocol. ».

Unfortunately, there are significant limitations to islet cell culture. Transplant recipients are forced to take immunosuppressive medications that come with a grocery list of side effects, such as high blood pressure and an increased risk of infection.. Then there is the lack of supply – organ donation – and the risk that, in most cases, the diabetic will slowly have to reintegrate their insulin over the years..

The stem cell therapy developed by Dr.. Shapiro suggests that he does not have any of these drawbacks. The University of Alberta team expects a single injection – with possible replacements – of insulin-producing cells derived from human stem cells.. No need for immunosuppressants or organ donation.

Now, the team is ready to move on to human trials. The only obstacle: money. A small group of volunteers, heading into 2022, wants to raise $ 22 million by 2022 to help bring in Dr.. The new treatment for Shapiro is in the next phase of trials.

“We want to turn diabetes into a cold-like illness; it has come and gone. “Be one in a million donations of $ 22 today and share it with your friends and family to raise awareness that treatment is on the horizon! Https: // t. co / 8lO118tBVA # worlddiabetesday # Diabetes pic. Twitter. com / NRSA6RKPDT

2022 will be the centenary of the first successful insulin injection. In 1922, Dr.. Frederick Banting and his young team, who work at the University of Toronto, saved the life of a 14-year-old boy named Leonard Thompson, who was dying of diabetes.

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Diabetes, Research, James Shapiro, Cure