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News Oct 272020
| Original story of Duke-NUS Medical School
Bats act as reservoirs for many zoonotic viruses, including SARS-CoV, MERS CoV, Ebola virus and – most likely – SARS-CoV-2, the pathogen that causes the ongoing coronavirus pandemic However, the molecular mechanisms deployed by bats to tolerate pathogenic viruses have remained unclear Now scientists at Duke-NUS Medical School in Singapore have discovered new molecular mechanisms that allow bats to tolerate zoonotic viruses. without getting sick Published this week in the Proceedings of the National Academy of Sciences (PNAS), the study suggests that bats adopt unique strategies to prevent overactive immune responses, which protect them against disease caused by viruses zoonotic
The team examined three species of bats – Pteropus alecto (black bat), Eonycteris spelaea (cave nectar bat) and Myotis davidii (David’s myotis bat) – and identified the mechanisms that balance the activity of key proteins that play a major role in mediating immunity and inflammatory responses in mammals These mechanisms allow bats to harbor and transmit zoonotic pathogens without triggering the harmful consequences of immune activation
One of the mechanisms used by bats is to reduce the levels of caspase-1, a protein that triggers a key inflammatory cytokine protein, interleukin-1 beta (IL-1β). they employ hinders the maturation of interleukin-1 beta cytokines through a finely tuned balance between caspase-1 and IL-1β
– Suppression of hyperactive inflammatory responses improves longevity and prevents age-related decline in humans Our findings may offer potential perspectives for the development of new therapeutic strategies that can control and treat human infectious diseases, at ???? said Professor Wang Linfa, senior author and correspondent for the Duke-NUS study. Emerging Infectious Diseases (EID) Program
« This study illustrates world-class research conducted by our talented faculty to advance fundamental scientific knowledge Professor Wang’s research is all the more important in the context of COVID-19, contributing to a better understanding of how zoonotic diseases persist in nature, and potentially helping new approaches to manage future outbreaks, â € said Professor Patrick Casey, Senior Associate Dean for Research, Duke-NUS Medical School Goh G, Ahn M, Zhu F, et al Complementary regulation of caspase-1 and IL-1β reveals additional mechanisms of attenuated inflammation in PNAS bats Published online October 22, 2020 doi: 101073 / pnas has been republished from the following materials Note: Material may have been modified for length and content For more information, please contact the cited source
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Viruses, natural reservoir, bats, zoonosis
News from the world – EN – Why do bats excel as viral reservoirs and do not get sick?
SOURCE: https://www.w24news.com
