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49ers stars Deebo Samuel and Christian McCaffrey went down with injuries in Sunday's loss to the Browns.
How good was Purdy on Sunday? Kyle Shanahan, who lives to order up runs, had to resist the urge to keep calling pass after pass.
The San Francisco 49ers dominate rivals Dallas, while Philadelphia defeat the Rams as both teams remain unbeaten on 5-0.
The Broncos moved on from a high-priced pass rusher this week, saying goodbye to Randy Gregory and sending him to the 49ers. He may not be the only Denver pass rusher headed out, NFL Network Insider Ian Rapoport reports.
Wide receiver Deebo Samuel remained out of practice Thursday, casting some question onto his availability for Week 4.
David Montgomery and the Lions got out to a big lead and held on to defeat the rival Packers on Thursday night.