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The Rabbitohs lead the Sea Eagles 16: 6 in their clash in Lottoland.
Canterbury are looking to spoil Penrith's 2021 goal when the teams meet at Bankwest Stadium on Saturday.
Newcastle and the Warriors head to the Central Coast to build on a promising Round 1 win. Connor Watson was put on a bench again and Sauaso Sue starts at the castle for the Knights.
The Storm drove home to a Flyer last week to maintain their remarkable first-lap record. But will a road trip against another Premier League aspirant undo it? Join us from 7.40 p.m.
The Parramatta Eels host the Melbourne Storm at home to kick off the second round of the NRL season.